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Mouse studies used 25 mg/kg IP BID
The BBB mechanisms and functions The main physiological roles of the BBB include providing nutrients to the brain and maintaining ionic balance, shielding the brain from external neurotoxins, and regulating neurotransmitter levels
The second kind of evidence is class-level
Math below assumes the research-vial protocol: 2 mg per day from a 10 mg vial reconstituted with 2.0 mL bacteriostatic water (5,000 mcg/mL concentration, 0.40 mL / 40 units per dose)
What's often left out of the headlines: most participants started the trials clinically obese and ended them still clinically obese, just less so
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